Área Técnica: Glaucoma
BRUCH’S MEMBRANE OPENING MINIMUM RIM WIDTH IN HEALTHY BRAZILIAN SUBJECTS
To describe Bruch’s membrane opening (BMO) minimum rim width (BMO-MRW) and retinal nerve fiber layer thickness (RNFLT) measurements with spectral-domain optical coherence tomography (SD-OCT) in a healthy Brazilian population and to evaluate the effect of age, axial length (AXL), central corneal thickness (CCT) and optic nerve head (ONH) anatomy on these parameters.
Healthy subjects were included in the study. One eye of each subject was selected randomly for analysis. Subjects had normal clinical examinations and visual fields. ONH (24 radial scans centered on BMO) and peripapillary circle scans (3.5-mm nominal scan diameter) were acquired relative to the fovea to BMO center axis (FoBMO) with the Spectralis SD-OCT (Figure 1). AXL and CCT data were also obtained. One eye of each subject was selected randomly for analysis. Associations between BMO-MRW and RNFL measurements with age, AXL, CCT and BMO area were evaluated.
204 healthy subjects (60% female) aged between 18 and 78 years (approximately 35 subjects in each decade) were included in the study. Neither global mean BMO-MRW or RFNLT were correlated with CCT (R2 = 0.01and R2 <0.01, respectively), AXL (R2 < 0.01 and R2 <0.01, respectively), or FoBMO (R2 = 0.01and R2 = 0.02, respectively). In univariate and multivariate analysis, global mean BMO-MRW and RFNL were associated with BMO area (R2 = 0.14, P < 0.01; R2 = 0.25, P < 0.01, respectively) and age (R2 = 0.07, P < 0.01; R2 = 0.07, P < 0.01, respectively).
This study provides BMO-MRW and RNFLT data obtained with SD-OCT in a population of healthy Brazilian individuals. Normative values of BMO-MRW and RNFLT should be adjusted for age and BMO area.